Peter R. Rehani,1 Hanaa Iftikhar,2 Motowo Nakajima,3 Tohru Tanaka,3 Zaid Jabbar,4 and Riyadh N. Rehani5
Conclusion: The provided analysis of the different mechanisms of action of antidiabetic medications reveals there are various means through which glycemic control can be achieved in the human body. Each class of drugs has a different mechanism of action, potency of glycemic control, and adverse reactions. Studies support the involvement of mitochondria in the pathology of diabetes, including its dysfunction, and the production of damaging free reactive oxidative species, as well as decreased insulin secretion and increased resistance. Assessing the mechanism of action of 5-ALA, an amino acid produced in the mitochondria and a newer supplement that has recently emerged on the market containing 5-ALA, studies show its effects on the mitochondria and its other metabolic effects including heme oxygenase-1 (HO-1) expression and cytoprotective products. Such findings suggest that the association between diabetes and the mitochondria could be utilized in managing type 2 diabetes, especially given the evidence of mitochondrial dysfunction to increase related risk factors . This is supported by the recent studies showing the safety of the 5-ALA supplement in the diabetic population, especially with the absence of hypoglycemic events so far in the studies conducted. Although currently the role of 5-ALA is as a supplement, it could lend a supporting role toward the successful treatment of diabetes in the future.
Journal Abstract: https://www.hindawi.com/journals/jdr/2019/4267357/